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It is principally associated with obesity, which may add to stigma and create a barrier to management [5, 6] It is acknowledged that there are different spectrums of the disease: the paediatric condition is unlikely to have similar pathophysiology driver as the adolescent and adult disease [7]

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High-resolution structural T1-weighted images were also acquired using a 3D magnetization-prepared rapid gradient echo (MPRAGE) sequence (TR/TI/TE = 2400/1000/2.22 ms, flip angle=8°, voxel size=0.8–1.0 mm isotropic, GRAPPA acceleration factor =2 in phase-encoding, partial Fourier =7/8 in both phase- and slice-encoding directions, 208 contiguous sagittal slices, total acquisition time =5 min 54 s)