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Tat-Beclin-1 Evidence# Tat-Beclin-1's evidence includes both direct peptide studies and genetic validation of its target pathway: Genetic lifespan data: The beclin 1 F121A knock-in mouse (constitutive disruption of the beclin 1-BCL2 interaction -- the same interaction Tat-Beclin-1 disrupts pharmacologically) showed increased autophagy, improved healthspan metrics, and extended lifespan (Fernandez et al., Nature 2018)
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