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Due to the lack of histone protection of mtDNA, the high mutability of the non-coding region and the restriction of its loop structure, ROS can further damage mtDNA, leading to a reduction in the copy number of mtDNA, damage the genes responsible for encoding some mitochondrial proteins and impair the function of mitochondria (87, 222, 223)
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Selenoprotein N in skeletal muscle: From diseases to function
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