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A third area of concern pertains to safety assessment and regulatory oversight, particularly for next-generation and genetically engineered strains

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45–47 Therapeutic landscape: What works and what’s next Indirect pathway suppression (approved) Anti-cytokine therapies upstream of NF-κB These medicines focus on pro-inflammatory cytokines (TNF-α, IL-1, IL-6), which are principal activators of the NF-κB pathway