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Excess ROS can cause DNA, protein, and lipid damage, leading to cell death [173]
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Subsequent studies have indicated that EGCG may stabilize HIF-1α through various regulatory pathways, including immunoglobulin-heavy-chain binding protein HSP 70 kDa protein 5 (BiP), prolyl 4-hydroxylase, HSP90 beta, and E2 ubiquitin-conjugating enzyme, among others
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