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A subset of clinical research has also demonstrated that adding B12 (and other B-vitamins) to existing antidepressant regimens can improve response rates compared to antidepressants alone, particularly when baseline B12 was suboptimal
Lifestar Pharma
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While there’s no definite cutoff for when larger amounts of B12 become unsafe, we somewhat arbitrarily recommend not taking more than 1,000 µg per day over the long-term without guidance from a physician
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