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This PKM2–HIF-1α–PD-L1 axis installs a formidable immune-metabolic checkpoint at the tumour–T cell interface (Steps 6–7), suppressing T cell effector functions by inhibiting the PI3K/Akt/mTOR signalling pathway and further impairing glycolytic flux, which collectively promotes immune evasion in high-glycolysis tumours 38
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