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AOD-9604 clinical data: One Phase 2b clinical trial was conducted in approximately 300 obese adults in Australia Results showed no statistically significant difference in weight loss between AOD-9604 and placebo groups The trial was considered a failure, and Metabolic Pharmaceuticals did not advance AOD-9604 to Phase 3 Total clinical weight loss data in humans: fewer than 500 participants across all studies Typical AOD-9604 results reported anecdotally: 1-3 kg over several months Semaglutide clinical data: The STEP clinical trial program included over 4,500 participants across multiple Phase 3 trials STEP 1 demonstrated 14.9% mean body weight loss (vs 2.4% placebo) over 68 weeks STEP 5 confirmed weight loss maintenance of approximately 15.2% over two full years STEP 4 showed that discontinuing semaglutide leads to weight regain, confirming its active role in fat loss The SELECT trial (17,604 participants) demonstrated a 20% reduction in major cardiovascular events Total clinical participants: over 20,000 across all weight loss and cardiovascular trials Safety and Side Effects AOD-9604 side effects: Generally well-tolerated in limited studies Injection site reactions Headache (infrequent) No significant GI side effects Critical caveat: The absence of side effects partly reflects the lack of robust biological activity in humans Semaglutide side effects: Nausea (most common, typically transient — resolves with dose titration) Vomiting, diarrhea, constipation Injection site reactions Rare reports of pancreatitis Well-characterized safety profile from extensive clinical trials Most GI side effects can be managed with proper dose titration For guidance on proper peptide injection technique to minimize discomfort, see our GLP-1 injection guide

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