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In addition, an increase in the histone H3 lysine 9 trimethylation (H3K9me3)-induced repressive chromatin state, particularly at long interspersed repeat element 1 (LINE1) retrotransposons 57 , characterized by increased expression of H3K9 and H3K27 methyltransferases, promotes the DTP phenotype and survival

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compiled from community dosing logs and reconstitution guides — documentation of what sources describe, not a recommendation): Self-reported starting doses begin around 125 mcg weekly for 2-4 weeks to assess tolerance, before increasing to 250 mcg