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Fungal-targeted nanoconstructs (FTNx), using antisense oligonucleotides against FKS1 and CHS3 , can inhibit fungal cell wall synthesis genes, reduce fungal burden and improve survival in murine candidiasis models, exhibit broad-spectrum antifungal activity, including against clinical isolates of Candida auris ( Li et al., 2025a)
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Peptides affecting similar pathways may produce diminishing returns rather than synergy
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