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Experimental vascular studies using isolated rat aorta preparations reported that BPC-157 modulated vasomotor tone and increased nitric oxide generation through activation of the Src–Caveolin-1–endothelial nitric oxide synthase (eNOS) signaling pathway [3]
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Long-term use: Clinical trials only ran 12 weeks, so long-term safety data (6+ months continuous use) comes from anecdotal reports
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