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11 It engages co‐ordination between the mitochondrial and the nuclear genomes, in a complex and multistep process (Figure 1) that involves: (i) mtDNA transcription and translation mtDNA transcription is activated by the family of PGC‐1 proteins (PGC‐1α, PGC‐1β and PGC‐1), from which PGC‐1α is considered the master regulator of mitochondrial biogenesis
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L-dopa cytotoxicity to PC12 cells in culture is via its autoxidation
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