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We then assessed the glutaminolysis pathway, including both oxidative glutaminolysis and the reductive carboxylation pathway, by conducting isotope tracing using 13 C 5 -L-glutamine (Figure 4H)

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Studies have demonstrated that chronic administration of AOD-9604 leads to adaptive changes in adipose tissue, including increased expression of beta-3 adrenergic receptors and enhanced sensitivity to lipolytic signals