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The F-statistics of MR ranged from 22.54 to 657.29, suggesting that weak instrumental bias may not have been substantial in our study ( Causal effect of endogenous antioxidants on the risk of six cancers The MR association estimates of the causal association between six endogenous antioxidants and the risks of six cancers are shown in Figure 3A, and detailed outcomes are shown in Supplementary Table S5