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Earlier work on the alpha-MSH fragment traces back to Hiltz and Lipton (1989)

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Minimizing Methylmalonic Acid Levels A potential problem with the IOM’s method for determining B12 requirements (see Institute of Medicine’s Recommendations above), is that a small percentage of people with neurological symptoms of B12 deficiency have normal blood parameters, including 13% of patients in one series of case studies (Lindenbaum, 1988)