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This likely accommodates the essential role of Egr1 indirectly controlling the expression of other genes, and thereby, neural activity, neural plasticity, and learning (Knapska & Kaczmarek, 2004), similar to the implied role of Egr1 gene in inflammation, myocardial injury (Rayner et al., 2013), brain injuries following transient focal ischemia (Tureyen, Brooks, Bowen, Svaren, & Vemuganti, 2008) or permanent occlusion of the middle cerebral artery (Beck, Semisch, Culmsee, Plesnila, & Hatzopoulos, 2008)

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A compound can produce compelling results in rats while behaving differently in humans due to differences in metabolism, absorption, dosing, tissue exposure, and disease biology