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In addition, researchers have also discovered an interesting phenomenon that in VSMCs, activation of PPAR-γ induces the expression of LO enzymes (12-LO and 15-LO) and the secretion of LO products (12-HETE and 15-HETE), and these LO products can further upregulate the expression of PPAR-γ-2, forming a positive feedback amplification loop to enhance the activity and function of PPAR-γ [172]