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Conclusions During evolution, mammals’ RBCs have lost nuclei, mitochondria, and other organelles, improving their efficiency in transporting and distributing oxygen and favoring the emergence of animal species with high energy demands
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These findings underscore the contribution of metabolic alterations to T2DM pathogenesis and implicate glutamine, QGR, and QER as promising biomarkers for tracking disease progression, insulin resistance, inflammatory activity, and mitochondrial dysfunction
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