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Automated processing and easy-to-report parameters can also help to streamline the annotation process
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For example, OH • can inhibit MAPK phosphatase to activate the ERK pathway [114, 115], oxygen free radicals can promote the phosphorylation of EGF and PDGF receptors, which are upstream of the ERK pathway [116, 117], and ROS can also activate the ERK pathway through the activation of Src kinase [118]
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