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This includes the following 2 : Dose – The amount of drug administered, denoted by the symbol D Dosing Interval – The time between drug dose administrations, denoted by the symbol T C max – The peak plasma concentration of a drug after administration t max – The time it takes to reach C max C min – The lowest (trough) concentration that a drug reaches before the next dose is administered Volume of Distribution – The volume in which a drug is distributed (varies) denoted by symbol V d – calculated by the Dose divided by the initial concentration Concentration – The amount of drug in a given volume (generally plasma in the case of humans) denoted by symbol C – calculated by the Dose divided by the volume of distribution 0 ,C ss Elimination Rate Constant – The rate at which a drug is removed from the body given as k e Elimination half-life – The time required for the concentration of a drug to reach half its original value – calculated by the natural log (2) divided by the elimination rate constant Clearance – The volume of plasma clear of a drug per unit time, given by symbol CL Bioavailability – The systematically available fraction of a drug given by symbol f Each drug will have its own C max and a different elimination rate constant, thus a different elimination half-life

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