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It adds complexity to current AD diagnosis methods involving measurement of pathology, and urges researchers to focus on more functional clinical endpoints for AD, such as scores on screening tests of cognitive performance like the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) or biomarkers of synaptic loss, such as positron emission tomography (PET) scans for the presynaptic marker SV2A, which has been reported to reflect synapse number ( Along these lines, a subfield of AD research is emerging to focus on understanding the origins and causes of resilience
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The Names Glutamine, glutamate, glutathione
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