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Mitochondrial dysfunction leads to the formation of O 2– , while the inflammatory response induced by cisplatin involves the upregulation of TNF-α, nicotinamide adenine dinucleotide phosphate oxidase, and inducible nitric oxide synthase (iNOS), which directly leads to NO – formation
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NMR studies performed in their work suggested that DPI adapts a conformation similar to molecule 1 in the insulin dimer but the conformer derived after restrained MD simulations resembles molecule 2
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