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The naturally occurring peptide GHK-Cu (GHK from glycyl-L-histidyl-L-lysine bound to a copper ion), which affects 31.2% of the human genes by either activating or deactivating them (based on a criterion of a reduction or increment in gene activity of more than 50%), meaning that it works by inducing epigenetic alterations in the cells

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Alcohol may also be a folate antagonist, as patients who are drinking spirits may develop megaloblastic anemia that will respond to normal quantities of dietary folate or to physiologic doses of folic acid only if alcohol is withdrawn