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A proteome study of mouse cerebral cortex, hippocampus, and cerebellum found that the abundance of enzymes of the fatty acid beta-oxidation pathway, including acetyl-CoA acetyltransferase 1 (ACAT1) and acyl-CoA dehydrogenase medium chain (ACADM), declined with aging (Gostomska-Pampuch et al., 2021), while DR led to a 4-fold increase in ACAT1 persulfidation and a decrease in ACADM persulfidation in mouse brain (Bithi et al., 2021)
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