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When drug resistance develops after a prolonged clinical response and a time window in which MRD is undetectable by radiological imaging, it is widely accepted that cell plasticity and non-genetic drug tolerance may have a crucial role in causing drug resistance
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In this randomized controlled trial, 48 adults with mild to moderate depression and/or anxiety participated in a 6-week study comparing three treatment groups: PI Therapy alone, PI Therapy with nutritional supplements, and CBT
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