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In rodent and cell work, NNMT knockdown or inhibition has been described as protecting against diet-induced weight gain and improving metabolic measures without reducing food intake [5] [6]
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Among these, vinpocetine-derived ionizable-lipidoid nanoparticles (VIP) have emerged as an interesting, promising brain-targeting platform model for gene delivery, addressing not only the challenge of crossing the BBB but also the critical issue of microcirculation disorders
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