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Germ cell tumors such as testicular tumors and choriocarcinoma increase estrogen levels, disrupting the androgen-estrogen equilibrium and thereby triggering male breast development ( 3.3 Widespread exposure to EDCs and population risks With the widespread use of various industrial products in daily life, exposure pathways to EDCs have permeated all aspects of daily existence

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However, previous studies have reported that methionine or SAM supplementation exerts an anti-inflammatory effect through suppressing the production of IL-6, tumor necrosis factor (TNF)-α, and IFN-β in LPS-stimulated inflammatory macrophages and microglial cells (58–60)