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The utility of the MGIA as a surrogate of protective efficacy has been demonstrated in mice, non-human primates and humans, allowing standardization and consistency in vaccine evaluation across different species (54–57)
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DNA Fragmentation DNA fragmentation results from increased oxidative stress and consequently leads to an increase in ROS that can oversaturate the sperm cell’s few antioxidant defense mechanisms and increase oxidative stress, which further directly damages DNA [45]
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