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While the treatment groups demonstrated trends toward weight reduction, the primary endpoint — body weight change at 24 weeks — did not achieve statistical significance at any dose compared to placebo, and Metabolic Pharmaceuticals discontinued further development for an obesity indication

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Native rhIGF-1 (mecasermin, brand name Increlex) is FDA-approved only for the long-term treatment of growth failure in pediatric patients with severe primary IGF-1 deficiency or with GH gene deletion who have developed neutralizing antibodies to GH