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Furthermore, the inhibition of glycolytic enzymes would cause the cell to shift its reliance on glycolysis to the pentose phosphate shunt, thus uncoupling the production of ATP and pyruvate from glycolysis and contributing to the growing anaerobic environment found in AD brain (133)

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Seek medical advice if you experience: New-onset insomnia or significant sleep disruption that persists after starting B12 supplementation Paradoxical fatigue : Worsening tiredness despite taking B12, which may indicate an underlying condition requiring investigation Neurological symptoms : Tingling, numbness, balance problems, or cognitive changes, which could suggest B12 deficiency or other neurological conditions Mood changes : Anxiety, agitation, or depression that develops or worsens after starting supplementation Palpitations or rapid heartbeat : Though rare, some individuals report cardiovascular symptoms that should be evaluated It's important to note that sleep disturbances may be unrelated to B12 supplementation