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it was further demonstrated that erastin-induced ATF3 does not appear to regulate SLC7A11 levels induced by erastin treatment (Wang et al., 2020a)

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As a key component of the ERS apoptotic pathway, Caspase-12 can translocate from the endoplasmic reticulum to the cytosol during ERS, where it activates Caspase-3 and initiates the apoptosis process, 59 as illustrated in detail in Figure 2C