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As follows, knockout of Nrf2 in mice (Nrf2 KO) substantially increased the susceptibility of mice to a broad range of chemical toxicity and disease conditions associated with oxidative pathology (5, 11–15)

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Researchers have therefore investigated whether CoQ10 supplementation can help support oocyte quality and reproductive outcomes.53 54 Systematic reviews suggest CoQ10 may improve certain outcomes in women undergoing assisted reproductive technology, including clinical pregnancy rates in some analyses.55 56 Ritual's 100mg dose is lower than many fertility studies, which often use 200–600mg daily, but it still adds a relevant mitochondrial-support ingredient to the formula