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With the advent of molecular profiling, many drug-induced DNA modification changes were found at synaptic plasticity genes, which can affect their expression and persist after cessation of drug use (Massart et al., 2015)
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Moreover, a portion of white adipocytes in SAT can adopt brown adipocyte-like characteristics, becoming what is called brite or beige adipocytes, in response to cold stimulation, exercise, and other stresses (20)
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