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However, the lack of a control group, open-label design, and small sample size limit interpretation of these findings, and intravenous MeCbl for this indication remains experimental.7 6.3 Neuropathic and Musculoskeletal Pain Methylcobalamin has been explored in several clinical studies as a potential adjunct in conditions involving neuropathic or musculoskeletal pain

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Histone modification The opening and closing of specific areas of the DNA through methylation or acetylation