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Pembrolizumab demonstrated a median progression-free survival (PFS) of 16.5 months versus 8.2 months with chemotherapy, corresponding to a hazard ratio (HR) of 0.60, and achieved an ORR of 43.8% (47)

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The most commonly used terms were “oxidative stress,” “oxidative stress,” “nutritional antioxidants,” “reactive oxygen species,” and “adrenal hormone imbalance.” The search was refined using Boolean operators (AND, OR) to ensure relevance to the review’s focus on the potential of nutritional antioxidants against oxidative stress linked with adrenal hormone imbalance