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Nevertheless, it has been shown that in the humans, the GST with the highest activity toward AFB 1 exo-epoxide is the polymorphic hGSTM1-1 which is absent in about 50% of individuals in most human populations
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Neurologically, ALD/AMN can manifest with highly variable phenotypes, ranging from very aggressive and rapidly fatal inflammatory CNS demyelination in young boys to a more slowly progressive adult form either with cerebral white matter inflammatory lesions, or a more indolent progressive myelopathy and peripheral neuropathy (Moser, 1997)
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