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SCD is particularly relevant as a potential warning sign of future cognitive decline
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In a mouse model of ischemic stroke, Semaglutide (an FDA approved GLP-1R agonist for type-2 diabetes mellitus) administration (30 nM/kg every 5 days until 28 days) significantly reduced levels of inflammatory cytokines (IL-1α, TNFα, and C1q), Iba-1 + microglia/macrophages, and C3d + /GFAP + A1 reactive astrocytes (Zhang et al., 2022)
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