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(New England Journal of Medicine) That evidence base is why GLP-1s are viewed clinically as foundational metabolic therapeutics rather than “just weight-loss drugs.” The “peptide wave”: what people usually mean (and why it’s not one thing) When patients say “I’m looking into peptides,” they’re usually referring to one (or more) of these buckets: Body composition / muscle-support peptides Often marketed to preserve lean mass during fat loss or improve training adaptation