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The Patient-Reported Outcome Measurement Information System (PROMIS-10), which measures a combination of physical, mental, and social determinants of health [55], as well as the NeuroQoL-fatigue, an 8–9 question survey about fatigue [56], correlate with ALSFRS-R scores [57] and are being incorporated more consistently across neurology trials, but are not specific to ALS

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IGF-1 restores body weight, alleviates microbial dysbiosis and immaturity, and normalizes the microbiome to that seen in the ad libitum group, independent of diet [54]