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Novel covalent inhibitors such as ML210, which uses nitroisoxazole as a prodrug form and covalently binds GPx4 after intracellular conversion to an electrophilic moiety, have selectivity and pharmacokinetic properties superior to that of chloroacetamide inhibitors, and BCP-T.A, a thiazole analog containing an alkyne-based electrophilic moiety, has been found to have inhibitory activity on specific cells up to the low-nanomolar level with high selectivity
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Ulcerative Colitis A study among 168 people with ulcerative colitis in remission found that taking 400 mg of NAC twice daily (800 mg/day) for 16 weeks while slowly discontinuing prednisolone helped maintain remission by week 22
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