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84 reported GDF11 as a rejuvenating agent that protects the aged heart, the same group proposed that GDF11 exerts anti-aging effects on the brain, which was supported by the improvement of the cerebral vasculature and the enhancement of neurogenesis after the treatment of old mice with recombinant GDF11 proteins 100
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Ingested glutathione is broken down in the intestine by an enzyme called gamma-glutamyltransferase before it reaches circulation, and most cells cannot take up intact glutathione anyway
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