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The primary limitation of this study is that, despite the expected high number of participants (n = 400), the randomization into multiple intervention groups (low-histamine diet versus control, animal- and plant-based supplementation, and two dosage levels of the latter) results in a smaller sample size per group, which could potentially reduce the statistical power of the analyses

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Evidence From Wound Models Animal and laboratory studies have demonstrated improved healing rates in models of: burns surgical wounds skin injuries These studies often show faster tissue repair and improved structural outcomes in treated tissues