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For example, curcumin, resveratrol, and capsaicin have shown potential in preclinical studies, showing effects such as modulation of inflammatory cytokines, reduction in oxidative stress, and interaction with nociceptive receptors, which may contribute to pain relief [9]

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consistent with a recent large study in antipsychotic-naïve FEP ( n = 70) that reported negative findings in the dACC [44])