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The efficacy of oral NAC has been examined in individuals with COPD, IPF, and fibrosing alveolitis with varying degrees of success [53–55] (Table 2)

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It was found that the rate constants of luteolin and rutin in the initial rapid stage of the reaction in the free radical 2,2-Diphenyl-1-picrylhydrazyl (DPPH) experiment were much higher than the rate constants of taxifolin, iodine diol, etc., which may be related to the presence of 2,3-double bonds leading to the increase of resonance structure, allowing electrons to delocalize from the aromatic oxygen group on the B-ring to the C-ring, thereby increasing the reaction rate with the peroxide group