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In IL-10 (−/−) mice, it alleviates colitis by reducing colonic lamina propria CD4+ T cells, lowering TNF-α and IFN-γ levels, inhibiting epithelial cell apoptosis, increasing tight junction protein (occludin and ZO-1) expression, and enhancing intestinal barrier function [117]
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Therefore, we chose 3 mM as the experimental dose of GSH for the Fabry kidney organoid model
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