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These Cys residues seem to be important for Tau stability and its interaction with microtubules, and Cys-322 can affect tau aggregation (Prifti et al., 2021)
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To study the effect of the reduced GCG expression after CK2 inhibition under physiological conditions, mice were treated with CX-4945 or DMSO (as control) for 3 days and plasma GCG and insulin levels were examined
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