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Compared to free curcumin, CurNisNp (21 mg/kg ≈ 60 mg/kg free curcumin) shows superior efficacy, reducing MDA from 0.78 ± 0.06 to 0.18 ± 0.01 μmol/g (∼77% reduction), increasing total thiols from 33.74 ± 3.69 to 48.71 ± 7.99 nmol/mg (∼44% increase), and enhancing SOD from 11.16 ± 1.17 to 16.32 ± 2.28 units/mg (∼46% increase), while also significantly lowering cTnI and preventing atrial fibrillation, demonstrating improved cardioprotection at a lower equivalent dose (Nabofa et al., 2018)