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My understanding of the need/benefit for IA is that injecting into the synovial fluid achieves a far higher local peak concentration of GH (and hence saturation of local receptors) than could be achieved if systemic GH had to seep into the synovial fluid

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WEIGHT:70 MG

Mechanistically, they attenuate aldosterone-driven sodium retention, glomerular hyperfiltration, and TGF-β1-mediated collagen deposition in mesangial cells (117)