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Nonetheless, these findings underscore the intricate and bidirectional relationship between metabolism and immune regulation and highlight steroid hormones as key modulators of immunometabolic activity across multiple immune cell types ( Figure 1 )
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Studies have indicated that cPLA2α is overactivated in ischemic brain tissue via N-methyl-D-aspartate (NMDA) receptor/Ca2+ and thrombin pathways, promoting the mobilization of AA (Xu et al., 2024
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