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Plasma protein expression in FM has been correlated with pain severity, with an upregulation of proteins involved in immune and inflammatory processes, including upregulation of ceruloplasmin, a key acute-phase reactant (Ghafouri et al., 2023)
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It has long been known, for example, that whereas many MOPr agonists such as [D-Ala 2 , N -MePhe 4 ,Gly-ol 5 ]enkephalin (DAMGO) and etorphine are able to induce arrestin interaction with the MOPr and lead to extensive MOPr internalization, other agonists such as morphine are not (Keith et al ., 1996
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